Timely and appropriate invasive mechanical ventilation is one of the important treatment meth⁃ ods for critical COVID ⁃19 patients recommended by the current guidelines. However，how to accurately evaluate and effectively treat critically ill patients with invasive mechanical ventilation is very important for reducing the heterogeneity of treatment and improving the prognosis of COVID⁃19 patients with invasive mechanical ventilation in different regions，especially in primary hospitals. Based on the recommendations from previous clinical practice guidelines，the National Health Technology Promotion and Application Service Platform of China Medical and Health Development Foundation made this practical procedure of invasive mechanical ventilation in adult critical COVID⁃19 patients，in order to promote the standard application of invasive mechanical ventilation in the treatment of adult critical COVID⁃19 patients. 【Key words】 critical； coronavirus disease 2019； invasive mechanical ventilation； practical procedure